Journal of Yeungnam Medical Science

Han Ku Moon

11 Articles

A Case of Hemiconvulsion-Hemiplegia-Epilepsy Syndrome: Han Ku Moon; Yeungnam Univ J Med. 2007;24(2 Suppl):S689-695. Published online December 31, 2007; DOI: https://doi.org/10.12701/yujm.2007.24.2S.S689

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Abstract PDF: Hemiconvulsion-Hemiplegia-Epilepsy syndrome is characterized by a prolonged unilateral convulsion in the form of status producing a persisting hemiplegia during a febrile illness, followed by epilepsy. It occurs in a child, between 5 months and 4 years old, with a peak incidence during the first 2 years of life. Although the etiologies of this syndrome are diverse, preexisting asymptomatic lesion of perinatal or prenatal origin is found in a number of cases. I experienced a case of HHE syndrome in a 11 month old girl with abnormal perinatal history and developmental delay, who showed predominant right sided focal motor seizures followed by right hemiparesis.

Intrathecal Methotrexate Induced Neurotoxicity in Children with Acute Lymphoblastic Leukemia: Jae Min Lee, Han Ku Moon, Jeong Ok Hah; Yeungnam Univ J Med. 2007;24(2 Suppl):S761-769. Published online December 31, 2007; DOI: https://doi.org/10.12701/yujm.2007.24.2S.S761

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Abstract PDF: Central nervous system (CNS) prophylaxis is an essential component of the treatment in childhood acute lymphoblastic leukemia (ALL). Methotrexate (MTX) is an dispensable antimetabolite for treatment of ALL. High-dose (HD) MTX and intrathecal (IT) MTX have improved the prognosis and reduced the rate of CNS relapse. However, the drug also has a significant toxic effect on the CNS and can potentially lead to severe neurologic morbidity. The overall incidence of acute MTX induced neurotoxicity has been estimated to be 0.8∼10% of treated children, depending on the amounts of MTX and leucovorin in the treatment protocol. Acute neurotoxicity generally develops within 5∼14 days after IT MTX or HD MTX and may include headache, nausea, emesis, lethargy, altered mental status, blurred vision, aphasia, hemiparesis, and seizure. Diffusion weighted MRI shows restricted diffusion of water in brains of patients with ALL who experienced stroke-like event after IT MTX. We report the cinical and imaging findings of acute neurotoxicity in two patients after intrathecal administration of MTX for CNS prophylaxes of ALL.

A case of incontinentia pigmenti developed in a male newborn infant.: Min Jeong Cho, Son Moon Shin, Han Ku Moon; Yeungnam Univ J Med. 1998;15(2):381-390. Published online December 31, 1998; DOI: https://doi.org/10.12701/yujm.1998.15.2.381

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Incontinentia pigmenti is characterized by irregular linear blisters with erythematous lesions which are developed from birth or later, verrucous papules on the extremities which are noted after a few weeks or months, and the appearnace of streaks, spots and swirls of hyperpigmentation. This disorder is known as a systemic disorder caused by a defect at the developmental stage of organs originated from ectoderm or mesoderm. We experienced an incontinentia pigmenti in a male newborn infant who did not have any family history and had cutaneous lesions, which were in bullous and verucous stages, ophthalmic problems, and neurologic abnormalities.

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Case of a Male Newborn with Incontinentia Pigmenti Initially Misdiagnosed as a Recurrent Skin Infection
Sang Ho Park, Kyung-Hwa Nam, Yo Han Ho
Neonatal Medicine.2020; 27(3): 141. CrossRef

A Study on the Bone Density in Newborn Infants: Difference of the Bone Mineral Density according to the Gestational Age and the Birth Weight.: Eun Sil Lee, Son Moon Shin, Han Ku Moon, Yong Hoon Park, Kwang Hae Choi; Yeungnam Univ J Med. 1997;14(2):383-392. Published online December 31, 1997; DOI: https://doi.org/10.12701/yujm.1997.14.2.383

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Abstract PDF: To study the differenced of bone mineral density according to the gestational ages and the birth weight and get a reference data for the diagnosis of metabolic bone diseases in the newborn infants, bone mineral densities of the lumbar vertebrae were measured in fifty-three newborn infants bone at Yeungnam University Hospital from March 1, 1995 to February 28, 1997, whose gestational ages were between 28+3 and 41+3 weeks and who had no intrauterine growth retardation, using dual energy X-ray absorptiometry (X-R 26, Norland, USA) within seven days of life. 1. There was no sexual difference in bone mineral density. The bone density increased significantly as gestational age increased from 0.149+/-0.009 g/cm2 at 28-30wks to 0.229+/-0.034 g/cm2 at 39-41wks of gestational age (p<0.05), but there was no significant difference between bone mineral density at 33-34wks and 35-36wks. There was positive linear correlation netween gestational age and bone mineral density (Y=7.5?10-3X-0.082, r=0.7018, p<0.001). 2. The bone mineral density increased significantly as the birth weight increased from 0.158+/-0.020 g/cm2 in 1,000-1,499 g to 0.251+/-0.021 g/cm2 in 3,500-4,000 g of the birth weight (p<0.05), but there was no significant difference between bone mineral densities in 1,000-1,499 g and 1,500-1,999 g of the birth weight. There was positive linear correlation between the birth weight and the bone mineral density (Y=3.9?10-5X+0.093, r=0.7296, p<0.001). There were positive correlations between the bone mineral density and gestational age, and between the bone mineral density and the birth weight. It can be used as a reference data for the further study on the bone mineral metabolism in the newborn infants including preterm babies.

A Case of Bartter's Syndrome with a Seizure Disorder Associated with Subdural Hematoma.: Jae Jun Lee, Han Ku Moon, Yong Hoon Park; Yeungnam Univ J Med. 1994;11(2):388-397. Published online December 31, 1994; DOI: https://doi.org/10.12701/yujm.1994.11.2.388

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Bartter's syndrome is a rare tubular disorder characterized by hypokalemic, hypochloremic metabolic alkalosis, hyperreninemic, hyperaldosteronism, hyporesponsiveness to pressor agents and juxtaglomerular apparatus heperplasia. We report a case of Bartter's syndrome of a 5 month-old male infant with subdural hematoma who was confirmed by characteristic clinical, laboratory findings and kidney biopsy.

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Furosemide induced medullary nephrocalcinosis mimicking Bartter syndrome
Sohee Kim, Chanhee Kyung, Yong hoon Kim, Jang ho Cho, Changhyeok Hwang, Jung Eun Lee
Yeungnam University Journal of Medicine.2014; 31(1): 21. CrossRef

A clinical study on children with delayed language development.: Jeong Ho Kim, Han Ku Moon, Jeong Ok Hah; Yeungnam Univ J Med. 1991;8(2):24-34. Published online December 31, 1991; DOI: https://doi.org/10.12701/yujm.1991.8.2.24

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Delayed emergence of speech or language are frequent causes for concern about development during early childhood. Delay in evaluation and proper management until school entry in more likely to result in frustration, anxiety and school failure. Many language disturbances and their attendant behavior disorders respond to intensive language therapy. Authors analyzed the medical records of 52 children with delayed language development evaluated during 30 months from January 1986 through June 1988. The results were as follows: 1. The majority of cases were evaluated at the age of 2-2.9 year old (16 cases, 30.8%) and 3-3.9 year old (11 cases, 21.2%) 2. Male to female ratio was 3:1 3. The most common cause was mental retardation (53.8%), followed by developmental language disorder (23.1%) and autism (13.5%) 4. The most common associated condition was dysarticulation (17.3%), followed by strabismus (9.6%) and seizures (7.7%) 5. Special education was recommended in cases of 23 (44.2%), speech therapy in 12 cases (23.1%) and consultation to child psychiatry in 7 cases (13.5%) Making diagnosis of underlying disorders in not simple because assessment of intelligence in young children in difficult and only a few tests are standardized. More detailed study on children with delayed language development and development of psychometric tests for handicapped children are necessary, especially in Korea.

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The usefulness of diagnostic tests in children with language delay
Seung Taek Oh, Eun Sil Lee, Han Ku Moon
Korean Journal of Pediatrics.2009; 52(3): 289. CrossRef

A Clinical Study on Low Birth Weight Infants.: Han Ku Moon, Jung Ok Kim, Jae Honng Park, Son Moon Shin, Jeong Ok Hah; Yeungnam Univ J Med. 1987;4(2):97-103. Published online December 31, 1987; DOI: https://doi.org/10.12701/yujm.1987.4.2.97

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Abstract PDF: Neonatal and obstetrical problems related to the low birth weight infants were evaluated by a retrospective review of the medical records of the 186 low birth weight infants born at Yeungnam University Hospital during 3 years and 8 months from May 1, 1983 to February 28, 1987. The results were as follows: 1. The incidence of the low birth weight infants was 4.98% among 3,803 live births. 2. Male to female ratio was 1.02:1. 3. The incidence of the low birth weight infants was lowest in mothers of 25 to 29 years, increased in mothers of 19 years of less and 30 to 39 years significantly. 4. There was no difference in the incidence of low birth weight infants between primiparous and multiparous mothers. 5. Common obstetrical complications associated with low weight infants were multiple pregnancy, toxemia and premature rupture of membrane in order of frequency. 6. Common neonatal problems in low birth weight infants were jaundice, idiopathic respiratory, distress syndrome, asphyxia and metabolic derangement such as hypocalcemia and hypoglycemia in order of frequency.

The Acute Intermittent Peritoneal Dialysis in Acute Renal Failure of Newborn and Young Infants.: Yong Hoon Park, Han Ku Moon; Yeungnam Univ J Med. 1986;3(1):375-382. Published online December 31, 1986; DOI: https://doi.org/10.12701/yujm.1986.3.1.375

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Abstract PDF: We studied the effects of the acute intermittent peritoneal dialysis in severe acute renal failure of 1 newborn infant and 2 young infants during 18 months period from February 1985 to April 1986. The predisposing illnesses were severe acute gastroenteritis with dehydration. Reye's syndrome, and bilateral nephrolithiasis with hyperuricemia. The concomitant illnesses were severe hypernatremia, hyponatremia, hyperkalemia, hypocalcemia, hypoglycemia, DIC (disseminated intravascular coagulopathy). Paralytic ileus, metabolic acidosis and gastrointestinal bleeding. As a dialysate, Imperinol solutionR, 1.5% was used in all cases. The cycles of dialysis were 8, 16, and 41 times in each cases. Observed complications during dialysis were leakage, and abdominal wall and scrotal swelling in 2 cases, hyperglycemia in 1 case, and peritonitis in 1 case. Acinetobacter calcoaceticus was cultured in peritoneal fluid of peritonitis. These complications were treated by stopping dialysis in leakage and abdominal wall swelling, insulin therapy in hyperglycemia, and intraperitoneal and systemic antibiotics therapy in peritonitis. We experienced improvements of severe acute renal failure with variable concomitant illnesses by acute intermittent peritoneal dialysis despite of the treatable complications of dialysis in all cases.

9 Cases of Non-chromosomal Multiple Malformation Disorders with Psychomotor Retardation.: Han Ku Moon, Yong Hoon Park, Jeong Ok Hah; Yeungnam Univ J Med. 1986;3(1):367-374. Published online December 31, 1986; DOI: https://doi.org/10.12701/yujm.1986.3.1.367

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Abstract PDF: To make better clinical diagnosis, authors reviewed 9 patients of nonchromosomal multiple malformation disorders with psychomotor retardation, who were evaluated at pediatric department of Yeungnam University hospital for recent 2 years. We could make clinical diagnosis in 5 patients out of 9 as Aarskog syndrome, BeckwithWiedemann syndrome, Hallermann-Streiff syndrome, Rubinstein Taybi syndrome and Weaver syndrome. But even in diagnosed cases, there were many discrepant findings in comparison with typical cases of reference literatures and family history was positive in only one case. Moreover we could not make diagnosis in 4 patients. Therefore we think it is necessary to make a survey of unique pattern, incidence, distribution and etiologic factors of malformation disorders in our country by geneticist and pediatrician as well as to improve the laboratory aids for better diagnosis and genetic counseling.

Clinical Investigation of Childhood Epilepsy.: Han Ku Moon, Yong Hoon Park; Yeungnam Univ J Med. 1985;2(1):103-111. Published online December 31, 1985; DOI: https://doi.org/10.12701/yujm.1985.2.1.103

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Abstract PDF: Childhood epilepsy which has high prevalence rate and inception rate is one of the commonest problem encountered in pediatrician. In contrast with epilepsy of adult, in childhood epilepsy, more variable and varying manifestations are found because the factors of age, growth and development exert their influences in the manifestations and the courses of childhood epilepsy. Moreover epilepsy children have associated problems such as physical and mental handicaps, psychological disorders and learning disability. For these reasons pediatrician who deals with epileptic children experiences difficulties in making diagnosis and managing them. In order to improve understanding and management of childhood epilepsy, authors reviewed 103 cases of epileptic patients seen at pediatric department of Yeungnam University Hospital retrospectively. The patients were classified according to the type of epileptic seizure. Suspected causes of epilepsy, associated conditions of epileptic patients, age incidence and the findings of brain CT were reviewed. Large numbers of epileptic patients (61.2%) developed their first seizures under the age of 5. The most frequent type of epileptic seizure was generalized tonic-clonic, tonic, clonic seizure (49.5%), followed by simple partial seizure with secondary generalization (17.5%), simple partial seizure (7.8%), atypical absence (5.8%) and unclassified seizure (5.8%). In 83.5% of patients, we could not find specific cause of it, but in 16.5% of cases, history of neonatal hypoxia (4.9%), meningitis (3.9%), prematurity (1.9%), small for gestational age (1.0%), CO poisoning (1.0%), encephalopathy (1.0%) were found. 30 cases of patients had associated diseases such as mental retardation, hyperactivity, delayed motor milestones or their combinations. The major abnormal findings of brain CT performed in 42 cases were cortical atrophy, cerebral infarction, hydrocephalus and brain swelling. This review stressed better designed classification of epilepsy is needed and with promotion of medical care, prevention of epilepsy is possible in some cases. Also it is stressed that childhood epilepsy requires multidisciplinary therapy and brain CT is helpful in the evaluation of epilepsy with limitation in therapeutic aspects.

A Case of Alveolar Rhabdomyosarcoma Originating from the Chest Wall.: Chun Dong Kim, Jeong Ok Hah, Hyun Mo Koo, Byung Ryul Choi, Han Ku Moon, Yong Hoon Park, Jin Gon Jun, Tae Sook Lee; Yeungnam Univ J Med. 1984;1(1):207-212. Published online December 31, 1984; DOI: https://doi.org/10.12701/yujm.1984.1.1.207

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Abstract PDF: Rhabdomyosarcoma originating from the chest wall is a rare malignant tumor in children and was considered to be guarded in prognosis previously. However, recent advances in multidisciplinary treatment of rhabdomyosarcoma in children have improved the disease free survival rate. Authors report a case of alveolar rhabdomyosarcoma, stage III, originating from the chest wall who is surviving free of disease for 15 months with aggressive chemotherapy and radiotherapy.

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